Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CGAS, STING1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| CXCL10 | co_associated_with | gene | 0.40 |
| PFN1 | co_associated_with | gene | 0.40 |
| Cell-type specific vulnerability markers | co_associated_with | gene | 0.40 |
| Mitochondrial respiratory complexes and inflammatory cytokine receptors | co_associated_with | gene | 0.40 |
| TNFRSF25 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AP1S1 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| cGAS-STING Senescence Circuit Disruption | 0.486 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] | Fazal F, Dar NJ, Ahamad S, Khan S, Bano | Mol Aspects Med | 2026 | 0 |
| Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] | Lu C, Wang W, Fu YX | Nat Rev Cancer | 2026 | 0 |
| Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200] | Li D, Cui G, Yang K, Lu C, Jiang Y et al | Nat Cell Biol | 2026 | 0 |
| cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] | Solomon J, Mandal S, Aran KR | Gene | 2026 | 0 |
| Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867] | Li L, Ye Q, Ma J, Wang Z, Liu T et al. | Cancer Cell | 2026 | 0 |
| DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251] | Tomaskovic I, Prieto-Garcia C, Boskovic | Science | 2026 | 0 |
| Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] | Qin H, Yang L, Du J, Xu X, Chen Z et al. | Int Immunopharmacol | 2026 | 0 |
| EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and pr [PMID:41738749] | Zhang Q, Abudukadier A, Chen H, Xiong L, | Microbiol Spectr | 2026 | 0 |
| Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243] | Zhang M, Lan Y, Yue Q, He J, Li L et al. | J Nanobiotechnology | 2026 | 0 |
| STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053] | Ye R, Wang S, Hu Y, Pan Y, Zheng W et al | Science | 2026 | 0 |
| Development of UM-200: A Novel Alkyne Amide-Based Inhibitor of the cGAS-STING Pa [PMID:41866990] | Barasa L, DeOrsey L, O'Reilly MD, Choudh | J Med Chem | 2026 | 0 |
| Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STIN [PMID:41910318] | Yang LM, Lu Y, Levine MS, Wang X, Shi YQ | J Am Chem Soc | 2026 | 0 |
| African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral [PMID:41937559] | Li X, Ren B, Zhang D, Dan M, Liu D et al | Autophagy | 2026 | 0 |
| Microvesicle release drives cycles of mitophagy flux disruption and inflammatory [PMID:41941625] | Song R, Ma Y, Wan J, Hao S, Chen B et al | Proc Natl Acad Sci U S A | 2026 | 0 |